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- Title
The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?
- Authors
Katsimbri, Pelagia; Korakas, Emmanouil; Kountouri, Aikaterini; Ikonomidis, Ignatios; Tsougos, Elias; Vlachos, Dionysios; Papadavid, Evangelia; Raptis, Athanasios; Lambadiari, Vaia; Gabbianelli, Rosita
- Abstract
Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis' natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro- and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis.
- Subjects
PSORIATIC arthritis; LIPID metabolism; OXIDANT status; OMEGA-3 fatty acids; UNSATURATED fatty acids; PHENOTYPES; MEDITERRANEAN diet
- Publication
Antioxidants, 2021, Vol 10, Issue 2, p157
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox10020157