CANNABIDIOL OIL ATTENUATES OXIDATIVE STRESS IN THE BRAIN OF STZ-INDUCED DIABETIC RATS.

Vesna, Trpchevska; Elena, Rafailovska; Gjoshe, Stefkov; Suzana, Dinevska-Kjovkarovska; Biljana, Miova

Diabetes mellitus adversely affects brain function through various mechanisms, including glycotoxicity, vascular damage, blood-brain barrier (BBB) disruption, mitochondrial dysfunction, insulin resistance, synaptic insufficiency, and neuroinflammation. Among these, oxidative stress emerges as a pivotal player in the multifaceted impairment of brain function. This study investigates the ability of cannabidiol (CBD) to reduce oxidative stress in the brain of diabetic rats, taking into account its recognized neuroprotective and antioxidant effects. CBD oil extract, obtained through CO2 extraction from decarboxylated Cannabis flos and diluted with olive oil to 25% (w/w), was administered to streptozotocin (STZ)-induced diabetic rats (50mg/kg) over a 45-day treatment period. Biomarkers for oxidative stress and the activity of antioxidative enzymes in the brain were assessed. The administration of CBD oil in diabetic animals resulted in substantial increase in the activity of both glutathione peroxidase and glutathione reductase, accompanied by increase in glutathione content in the brain of diabetic rats. Moreover, CBD-treatment significantly increased the activity of catalase and superoxide dismutase as well as the ferric ion reducing antioxidant power-FRAP value, while decreasing malondialdehyde levels in the brain. The results suggest a promising role for CBD oil extract in ameliorating oxidative stress and supporting antioxidative mechanisms in the context of diabetesinduced brain dysfunction. This highlights the potential of CBD as a natural therapeutic agent, emphasizing its role in preserving brain health.

OXIDATIVE stress; CANNABIDIOL; GLUTATHIONE reductase; RATS; GLUTATHIONE peroxidase

Genetics & Applications, 2024, p64

2566-2937

Academic Journal