We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The first molecular analysis of clinical isolates of VanA-type vancomycin-resistant Enterococcus faecium strains in Mainland China.
- Authors
Zheng, B.; Tomita, H.; Xiao, Y.H.; Ike, Y.
- Abstract
Aims: The aim of this study was to examine two VanA-type vancomycin-resistant Enterococcus faecium (VRE) strains that had been isolated from patients resident in mainland China. This is the first molecular analysis of clinical VRE strains being isolated in mainland China. Methods and Results: Two VanA-type VRE isolates were isolated from in-patients at hospitals located in the Chinese cities Beijing and Dalian and were designated C264 and I125. The plasmids pC264V (40 kbp) and pI125V (370 kbp) that were isolated from C264 and I125, respectively, carried a Tn 1546-like element encoding VanA resistance. The vancomycin-resistant plasmids pC264V and pI125V were transferred by filter mating at frequencies of 10−7 and 10−4 respectively. Sequence analysis of pC264V revealed that two IS 1216V sequences and an IS 1542 sequence were present within the Tn 1546-like element. pI125V had two IS 1216V insertions in the Tn 1546-like element. Conclusions: The two VanA-type vancomycin-resistant E. faecium (VRE) strains C264 and I125 were isolated from in-patients in Chinese hospitals. The vancomycin-resistant conjugative plasmids pC264V and pI125V plasmids isolated from these strains carried the Tn 1546-like element. The Tn 1546-like element was found to contain the insertion sequences IS 1216V and IS 1542. Significance and Impact of the Study: This is the first molecular analysis of VanA-type VRE strains from patients resident in mainland China.
- Subjects
CHINA; VANCOMYCIN; ENTEROCOCCUS; ANTIBACTERIAL agents; GLYCOPEPTIDE antibiotics; PATIENTS; PLASMIDS; MOBILE genetic elements; HOSPITALS
- Publication
Letters in Applied Microbiology, 2007, Vol 45, Issue 3, p307
- ISSN
0266-8254
- Publication type
Article
- DOI
10.1111/j.1472-765X.2007.02191.x