We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Measuring Executive Dysfunction Longitudinally and in Relation to Genetic Burden, Brain Volumetrics, and Depression in Prodromal Huntington Disease.
- Authors
Papp, Kathryn V.; Snyder, Peter J.; Mills, James A.; Duff, Kevin; Westervelt, Holly J.; Long, Jeffrey D.; Lourens, Spencer; Paulsen, Jane S.
- Abstract
Executive dysfunction (ED) is a characteristic of Huntington disease (HD), but its severity and progression is less understood in the prodromal phase, e.g., before gross motor abnormalities. We examined planning and problem-solving abilities using the Towers Task in HD mutation-positive individuals without motor symptoms (n = 781) and controls (n = 212). Participants with greater disease progression (determined using mutation size and current age) performed more slowly and with less accuracy on the Towers Task. Performance accuracy was negatively related to striatal volume while both accuracy and working memory were negatively related to frontal white matter volume. Disease progression at baseline was not associated with longitudinal performance over 4 years. Whereas the baseline findings indicate that ED becomes more prevalent with greater disease progression in prodromal HD and can be quantified using the Towers task, the absence of notable longitudinal findings indicates that the Towers Task exhibits limited sensitivity to cognitive decline in this population.
- Subjects
EXECUTIVE function; LONGITUDINAL method; BRAIN physiology; HUNTINGTON disease; VOLUMETRIC analysis; MENTAL depression; GENETIC disorders
- Publication
Archives of Clinical Neuropsychology, 2013, Vol 28, Issue 2, p156
- ISSN
0887-6177
- Publication type
Article
- DOI
10.1093/arclin/acs105