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- Title
Translation, Cultural Adaptation, and Validation into Romanian of the Myeloproliferative Neoplasm Symptom Assessment Form—Total Symptom Score (MPN-SAF TSS or MPN-10) Questionnaire.
- Authors
Găman, Mihnea-Alexandru; Scherber, Robyn Marie; Ursuleac, Iulia; Crişan, Ana Manuela; Bădeliţă, Sorina Nicoleta; Ionescu, Bogdan Octavian; Ghiaur, Alexandra Elena; Brînză, Melen; Pîrciulescu, Nicoleta; Lascăr, Toma Octavian; Diaconu, Camelia Cristina; Găman, Amelia Maria; Coriu, Daniel
- Abstract
Background: Patients with myeloproliferative neoplasms (MPNs) experience a high disease-related symptom burden. A specific instrument to evaluate quality of life (QoL), i.e., the MPN Symptom Assessment Form Total Symptom Score (MPN-SAF TSS; MPN-10), was developed. We conducted the translation, cultural adaptation, and validation into Romanian of the MPN-10. Methods: We translated the MPN-10 and tested its psychometric properties. Results: We recruited 180 MPN patients: 66 polycythemia vera (36.67%), 61 essential thrombocythemia (33.89%), 51 primary and secondary myelofibrosis (SMF) (28.33%), and 2 MPN-unclassifiable (1.11%). The mean TSS was 19.51 ± 16.51 points. Fatigue, inactivity, and concentration problems were the most cumbersome symptoms. We detected scoring differences between MPN subtypes regarding weight loss (p < 0.001), fatigue (p = 0.006), early satiety (p = 0.007), night sweats (p = 0.047), pruritus (p = 0.05), and TSS (p = 0.021). There were strong positive associations between TSS and inactivity, fatigue, and concentration problems, and moderate negative correlations between QoL scores and all MPN-10 items. Cronbach's α internal consistency coefficient was 0.855. The Kaiser–Meyer–Olkin construct validity test result was 0.870 and the Bartlett Sphericity Test was significant (p < 0.001). Symptom scores were loaded into one single factor according to the exploratory factor analysis. Conclusions: The Romanian MPN-10 version displayed excellent psychometric properties and is a reliable instrument for assessing symptom burden and QoL in Romanian MPN patients.
- Subjects
MYELOPROLIFERATIVE neoplasms; SYMPTOM burden; POLYCYTHEMIA vera; EXPLORATORY factor analysis; SYMPTOMS
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 11, p3284
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13113284