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- Title
Long-Term Results of Combination Treatment with Single-Dose Ranibizumab plus Photodynamic Therapy for Retinal Angiomatous Proliferation.
- Authors
Malamos, Panagiotis; Tservakis, Ioannis; Kanakis, Menelaos; Koutsiouki, Chrysoula; Kiskira, Evita; Mylonas, Georgios; Lakoumentas, John; Georgalas, Ilias
- Abstract
Purpose: To present functional and anatomic outcomes of combination therapy with ranibizumab and photodynamic therapy (PDT) in a series of retinal angiomatous proliferation (RAP) cases. Methods: A total of 17 eyes of 17 patients with RAP were included. Thirteen eyes were treatment naïve and 4 were already on ranibizumab monotherapy. Combined treatment with single-dose ranibizumab and PDT was performed on all treatment-naïve cases. Follow-up was performed every month for 6–38 months, using optical coherence tomography and indocyanine green angiography when necessary. Results: Overall, 6 out of 7 treatment-naïve cases with stage I or II disease manifested complete angiographic resolution of the hot spot with a single injection of ranibizumab plus PDT. In stage III disease, 7 out of 10 eyes showed persistent leakage immediately after the combined treatment. The rate of hot spot occlusion was found to correlate with the stage of disease (p = 0.05). There was a significant improvement in posttreatment BCVA for all patients regardless of disease stage (p = 0.02), which was more evident in the earlier stages. Improvement was also greater for treatment-naïve patients (p = 0.03). The posttreatment improvement in BCVA was strongly correlated with hot spot occlusion (p < 0.001). Conclusions: Single-dose modified anti-VEGF treatment in combination with PDT may provide long-term regression at the initial stages of RAP.
- Subjects
COMBINATION drug therapy; RANIBIZUMAB; PHOTODYNAMIC therapy; RETINAL diseases; OPTICAL coherence tomography; ANGIOGRAPHY
- Publication
Ophthalmologica, 2018, Vol 240, Issue 4, p213
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000487610