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- Title
Relationship between neutrophil to lymphocyte ratio and diabetic peripheral neuropathy: a systematic review and meta-analysis.
- Authors
Rezaei Shahrabi, Armin; Arsenault, Gabrielle; Nabipoorashrafi, Seyed Ali; Lucke-Wold, Brandon; Yaghoobpoor, Shirin; Meidani, Fatemeh Zari; Rahmati, Rahem; Ghaedi, Arshin; Khanzadeh, Shokoufeh
- Abstract
Background: The present study aims to review the existing scientific literature on the role of neutrophil to lymphocyte ratio (NLR) in diabetic peripheral neuropathy (DPN) to perform a meta-analysis on the available data. Methods: The electronic repositories Web of Science, PubMed, and Scopus were systematically explored starting from their establishment up until June 9, 2022. Results: Fifteen articles were included in the meta‐analysis after multiple screening according to the PRISMA guidelines. The combined findings indicated that individuals with DPN had higher levels of NLR in comparison to those without DPN (SMD = 0.61; CI 95% = 0.40–0.81, p < 0.001). In the subgroup assessment based on ethnicity, it was observed that diabetic patients with DPN exhibited increased NLR levels in contrast to those without DPN in studies conducted in India (SMD = 1.30; CI 95% = 0.37–2.24, p = 0.006) and East Asia (SMD = 0.53; CI 95% = 0.34–0.73, p < 0.001) but not in studies conducted in Turkey (SMD = 0.30; CI 95% = − 0.06–0.67, p = 0.104) and Egypt (SMD = 0.34; CI 95% = -0.14–0.82, p = 0.165). The pooled sensitivity of NLR was 0.67 (95% CI = 0.49–0.81), and the pooled specificity was 0.70 (95% CI, 0.56–0.81). The pooled positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR) of NLR were 2.30 (95% CI = 1.71–3.09), 0.45 (95%CI = 0.30–0.67), and 5.06 (95% CI = 3.16–8.12), respectively. Conclusion: NLR serves as a distinct marker of inflammation, and its rise in cases of DPN suggests an immune system imbalance playing a role in the development of the disease.
- Subjects
EGYPT; EAST Asia; TURKEY; NEUTROPHIL lymphocyte ratio; DIABETIC neuropathies; SCIENTIFIC literature; PEOPLE with diabetes; ODDS ratio
- Publication
European Journal of Medical Research, 2023, Vol 28, Issue 1, p1
- ISSN
0949-2321
- Publication type
Article
- DOI
10.1186/s40001-023-01479-8