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- Title
Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening.
- Authors
Yang, Cuiping; Wu, Wei; Yang, Yanping; Yang, Xiaojin; Sun, Jing; Zhang, Weiyu; Liu, Kun; Ying, Haifeng; Jiang, Songyao; Yu, Xiaojun; Shi, Yiqing; Zhou, Yufen; Zhu, Shiyan; Xu, Ying; Ding, Yanfei; Xie, Ling; Cai, Boer; Xin, Xiaorong; Chen, Ping; Zhao, Ren
- Abstract
Patient screening is important for early diagnosis of colorectal cancer (CRC). The present study aimed to compare the multitarget stool DNA (mt-sDNA) test with the fecal occult blood test (FOBT) for CRC screening. A total of 151 individuals were screened using colonoscopy, mt-sDNA and FOBT for the detection of CRC and adenoma. The results of the mt-sDNA test and FOBT were compared with colonoscopy to examine their sensitivity and specificity. Subsequently, the sensitivity and specificity of the mt-sDNA test were compared with those of FOBT in CRC and large adenoma. Stool samples were collected from patients with CRC (n=50) or large adenoma (n=51), as well as from normal controls (n=50). The mt-sDNA test outperformed FOBT in detecting CRC with a sensitivity of 90.0% (45/50) vs. 42.0% (21/50), advanced adenoma with a sensitivity of 70.6% (36/51) vs. 19.6% (10/51), stage I–III CRC with a sensitivity of 91.9% (34/37) vs. 29.7% (11/37), and stage IV CRC with a sensitivity of 84.6% (11/13) vs. 76.9% (10/13). In addition, the mt-sDNA test exhibited a specificity of 94.0% (47/50) in detecting CRC, which was superior to FOBT with a specificity of 90.0% (45/50). Therefore, the mt-sDNA test may have higher sensitivity and specificity compared with FOBT in diagnosing both CRC and advanced adenoma.
- Subjects
FECAL occult blood tests; EARLY detection of cancer; ADENOMA; DNA
- Publication
Oncology Letters, 2020, Vol 20, Issue 2, p1193
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.11674