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- Title
1,2-Naphthoquinone-4-sulfonic acid sodium salt as a reagent for spectrophotometric determination of rimantadine and memantine.
- Authors
Muszalska, I.; Sobczak, A.; Kiaszewicz, I.; Rabiega, K.; Lesniewska, M.; Jelińska, A.
- Abstract
A selective ultraviolet and visible spectrophotometric method ( UV-Vis) for the determination of memantine ( MM) and rimantadine ( RM) hydrochlorides after derivatization with 1,2-naphtoquinone-4-sulfonic acid sodium salt ( NQS) and extraction with dichloromethane was developed and optimized. The reaction of the NQS (0.7%, w/v solution) with memantine was carried out for 40 min in a buffer medium of NaOH/KCl (pH 12.0) at 80°C. A mixture of NQS (0.2%) and rimantadine was heated for 20 min at 50°C, in a medium of NaOH/KCl (pH 12.0). The linearity of the determinations of MM (0.05-0.60 mg/mL) and RM (0.05-0.30 mg/mL) was evaluated. LOD (28 mg/mL for MM, 11 mg/mL for RM) and LOQ (84 mg/mL for MM, 32 mg/mL for RM) values and parameters of precision and accuracy were determined. The UV-Vis method for the determination of rimantadine hydrochloride tablets was validated (selectivity, linearity, precision, accuracy).
- Subjects
SODIUM salts; SPECTROPHOTOMETRY; RIMANTADINE; MEMANTINE; DRUG tablets
- Publication
Journal of Analytical Chemistry, 2015, Vol 70, Issue 3, p320
- ISSN
1061-9348
- Publication type
Article
- DOI
10.1134/S1061934815030120