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- Title
Venetoclax plus hypomethylating agents in newly diagnosed acute myeloid leukemia patients with RUNX1::RUNX1T1: a retrospective propensity score matching study.
- Authors
Wang, Miao; Cao, Han-Yu; Tan, Kai-Wen; Qiu, Qiao-Cheng; Huang, Yuan-Hong; Ge, Shuai-shuai; Wang, Zi-Hao; Chen, Jia; Tang, Xiao-Wen; Wu, De-Pei; Xue, Sheng-Li; Li, Zheng; Dai, Hai-Ping
- Abstract
This letter published in the Blood Cancer Journal presents a retrospective study comparing the effectiveness of different treatment regimens for acute myeloid leukemia (AML) patients with the RUNX1::RUNX1T1 gene mutation. The study found that venetoclax combined with hypomethylating agents (VEN + HMA) was not more effective than the standard 7 + 3 chemotherapy regimen for these patients. However, the presence of co-mutations in chromatin-cohesin genes was associated with a better response to VEN + HMA. The study highlights the need for further research to determine the best treatment approach for AML patients with the RUNX1::RUNX1T1 mutation.
- Subjects
ACUTE myeloid leukemia; PROPENSITY score matching; VENETOCLAX; GENETIC mutation
- Publication
Blood Cancer Journal, 2023, Vol 13, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-023-00948-x