We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Incidences of steroid-induced diabetes mellitus and congestive heart failure in cats given non-immunosuppressive doses of methylprednisolone acetate: 1042 cats.
- Authors
Dutch, Wendy A.; Norsworthy, Gary D.; Mayfield, Milton R.; Mayfield, Jacqueline R.; Schmitt, Connie W.
- Abstract
Objective Corticosteroids are indicated to treat many feline diseases. However, side effects are a limiting factor in their use. The most concerning side effects are steroid-induced diabetes mellitus (SI-DM) and steroid-induced congestive heart failure (SI-CHF). This study aims to determine the incidences of these diseases in a large population of domestic cats seen at a privately-owned, feline-only practice. Animals Cats in the study were client-owned patients of Alamo Feline Health Center in San Antonio, Texas. Control cats (controls) were examined as part of their routine health care. Procedures The records of 732 cats that received methylprednisolone acetate (MPA) for various clinical indications were reviewed to determine how many developed SI-DM and SI-CHF. A similar record review of 310 controls was made to determine the incidence of spontaneous diabetes mellitus (Sp-DM) and spontaneous congestive heart failure (Sp-CHF). Control cats never received any oral or injectable corticosteroids. Results Of the cats that received MPA, 28 developed SI-DM (3.83%) and 6 developed SI-CHF (0.82%). Of the controls, 22 developed Sp-DM (7.10%) and 6 developed Sp-CHF (1.90%). Conclusion The incidences of developing SI-DM and SI-CHF were 3.83% and 0.82%, respectively; and the risk was not increased even when repeated doses of MPA were given. Clinical relevance
- Subjects
SAN Antonio (Tex.); CONGESTIVE heart failure; DIABETES; FELIDAE; METHYLPREDNISOLONE; CATS; ACETATES; CLINICAL indications; ADRENOCORTICAL hormones
- Publication
Canadian Veterinary Journal / Revue Vétérinaire Canadienne, 2023, Vol 64, Issue 11, p1051
- ISSN
0008-5286
- Publication type
Article