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- Title
Tunicamycin-induced degeneration in cone photoreceptors.
- Authors
Anderson, Don H.; Williams, David S.; Neitz, Jay; Fariss, Robert N.; Fliesler, Steven J.
- Abstract
Tunicamycin (TM), an inhibitor of dolichylphosphate-mediated protein glycosylation, was injected intravitreally into the eyes of diurnal rodents with cone-dominated retinas. Injection of 1 μg of the B2 isomer led to a progressive degeneration of the photoreceptor outer segments and disruption of the RPE-photoreceptor interface that took place over a 10-day period. Cone outer segments were shortened by postinjection day 6 and virtually absent by day 9. The microvilli that normally protrude from the apical surface of the retinal pigment epithelium were replaced by a fringe of shortened processes. The other retinal layers showed no morphological evidence of disruption. Retinal sensitivity, as measured by electroretinographic b-wave threshold, showed a significant and progressive decline over the 10-day course of the experiment that paralleled the disruption of retinal morphology. These results suggest that TM leads to similar morphological and electrophysiological effects on rod and cone photoreceptors.
- Publication
Visual Neuroscience, 1988, Vol 1, Issue 2, p153
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523800001425