We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Close linkage between genes which cause hairlessness in the mouse.
- Authors
Flanagan, S. P.; Isaacson, J. H.
- Abstract
1. A new semi-dominant gene called shaven (Sha) causes hairlessness in the mouse and it is closely linked to naked. Homozygous shaven mice never grow a first coat and adults grow a few short hairs only. Shaven heterozygotes grow a full coat which is greasy.2. The percentage recombination between shaven and naked was found to be 0·8%. Three-point tests with naked and caracul showed that the order of the three loci is either N–Sha–Ca or N–Ca–Sha.3. The failure of homozygous shaven mice to grow a coat is due to abnormal keratinization of the hairs in the follicles. The follicles were found to be deficient in sulphydryl groups.4. The greasiness of the Sha+ coat is due to the presence of a sudanophilic fluid in the hair medullae.5. The close linkage between the two genes with similar phenotypic effects is discussed.
- Publication
Genetics Research, 1967, Vol 9, Issue 1, p99
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S001667230001034X