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- Title
Valine-resistant mutants of Escherichia coli K-12.
- Authors
Glover, S. W.
- Abstract
Sixty-two mutants of E. coli K-12 resistant to 40 μg./ml. valine were isolated from a sensitive strain. Transduction experiments using phage P1 showed that one group of these mutants, val-r-C, is closely linked to leu, another group, val-r-B is closely linked to thr, and a third mutant, val-r-D57, lies between leu and thr. Conjugation experiments showed that the remainder of the mutants could be divided into three groups, val-r-A, val-r-E and val-r-F on the basis of their different times of transfer from Vhf donors to val-s F− recipients. All the mutants are sensitive to 10,000 μg./ml. valine; val-r-B and val-r-D mutants are resistant up to 80 μg./ml. valine; val-r-C mutants are resistant up to 1000 μg./ml. valine, and val-r-A, val-r-E and val-r-F mutants up to 5000 μg./ml. The functional significance of the genetic locations of these groups is discussed.
- Publication
Genetics Research, 1962, Vol 3, Issue 3, p448
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300003293