We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship Between Dopamine D<sub>2</sub> Receptor-Associated Responses and Operant Ethanol Self-Administration in the Rat: A Factor Analysis.
- Authors
Rogowski, Arthur; Rokicki, Dariusz; Kostowski, Wojciech; Bienkowski, Przemyslaw
- Abstract
Aims: To characterize the relationship between dopamine D2 receptor-associated responses and operant ethanol self-administration in Wistar rats. Methods: Thirty-two rats were first tested for apomorphine-induced sniffing and raclopride-induced catalepsy. Subsequently, the same subjects were initiated to lever press for ethanol in the sucrose-fading procedure. The subjects were allowed to respond for 8% v/v ethanol for 20 days. A factor analysis was used to characterize the relationship between D2-associated responses and parameters of sucrose and ethanol self-administration. Results: The analysis revealed three factors accounting for 88.3% of the total variability. The first factor comprised only parameters of ethanol-reinforced behaviour. Parameters of sucrose self-administration and cataleptic responses to raclopride loaded heavily on the second and third factors, respectively. None of the factors comprised apomorphine-induced stereotypy. Conclusions: It appears that there is no relationship between apomorphine-induced sniffing, raclopride-induced catalepsy and operant responding for ethanol in Wistar rats. Our results, combined with previous reports, suggest that D2 receptors are not primarily involved in the regulation of ethanol reinforcement.
- Subjects
DOPAMINE receptors; PHYSIOLOGICAL effects of alcohol; BRAIN
- Publication
Alcohol & Alcoholism, 2003, Vol 38, Issue 4, p305
- ISSN
0735-0414
- Publication type
Article
- DOI
10.1093/alcalc/agg081