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- Title
A clinicopathological study of nodal marginal zone B-cell lymphoma. A report on 21 cases.
- Authors
Traverse-Glehen, A.; Felman, P.; Callet-Bauchu, E.; Gazzo, S.; Baseggio, L.; Bryon, P. A.; Thieblemont, C.; Coiffier, B.; Salles, G.; Berger, F.
- Abstract
Aims : To report the clinicopathological findings of 21 cases of primary nodal marginal zone B-cell lymphoma (NMZL). NMZL is a recently characterized lymphoma and few series have been published. Methods and results : The clinical data were characteristic of a disseminated disease at presentation: presence of peripheral and abdominal lymph nodes, bone marrow involvement (62%), disease stage III and IV (76%), elevated lactate dehydrogenase (LDH) (48%). Other features included peripheral blood involvement (23%), anaemia (24%), thrombocytopenia (10%) and presence of serum M component (33%), while the previously reported association with hepatitis C virus and cryoglobulinaemia was not found. Relapses were frequent but the majority of patients receiving chemotherapy had a good initial response. Morphological features were heterogeneous and there were some differences compared with other marginal zone B-cell lymphomas (MZL). Pure monocytoid B-cell lymphomas were rare (10%) but a minor component of monocytoid B cell was observed more frequently (23%). Plasmacytoid or plasmacytic differentiation was a very common feature (61%). Large cells and a high mitotic count were also frequent (57%). Conclusion : NMZL can be distinguished from splenic MZL and extranodal MZL by its aggressive morphology and disseminated disease at presentation.
- Subjects
LYMPHOMAS; RETICULOENDOTHELIAL granulomas; BONE marrow; HEPATITIS C; LYMPHOPROLIFERATIVE disorders; BLOOD plasma; HEPATITIS viruses; LYMPH nodes; LYMPHATICS; IMMUNE system
- Publication
Histopathology, 2006, Vol 48, Issue 2, p162
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2005.02309.x