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- Title
Resveratrol: A Review on the Biological Activity and Applications.
- Authors
Bejenaru, Ludovic Everard; Biţă, Andrei; Belu, Ionela; Segneanu, Adina-Elena; Radu, Antonia; Dumitru, Andrei; Ciocîlteu, Maria Viorica; Mogoşanu, George Dan; Bejenaru, Cornelia
- Abstract
Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.
- Subjects
RESVERATROL; PLANT defenses; IMMUNOLOGIC diseases; HIGH-fat diet; NEURONS; RED wines
- Publication
Applied Sciences (2076-3417), 2024, Vol 14, Issue 11, p4534
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app14114534