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- Title
Dexamethasone and CD300a activation display additive inhibitory effect on human and murine mast cell functions.
- Authors
Gaur, Pratibha; Rahimli Alekberli, Fidan; Karra, Laila; Mankuta, David; Ben‐Zimra, Micha; Levi‐Schaffer, Francesca
- Abstract
Figure 1Aa shows that the combined treatment of Dex with anti-CD300a significantly reduced CBMCs release of GMCSF (by ~80%) compared to their mono-treatments (Dex ~42% and anti-CD300a ~49%). Taken together, our I in vivo i results demonstrate that in a model of anti-IgE inflammation where MCs are directly activated, there is a significant inhibitory effect by the combined treatment of Dex and anti-CD300a. Since a main function of both Dex and CD300a is their negative regulation of pro-inflammatory cytokine secretion in both CBMCs and BMMCs, we first evaluated their combined inhibitory effect on IgE-induced cytokine release.
- Subjects
TRYPTASE; CELL physiology; MAST cells; DUAL specificity phosphatase 1; CELL receptors; SECRETORY granules
- Publication
Clinical & Experimental Allergy, 2021, Vol 51, Issue 10, p1383
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.13872