We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An investigation of propolis in the treatment and prevention of radiation induced Mucositis in head and neck cancers.
- Authors
Bolouri, Abbas Javadzadeh; Pakfetrat, Atessa; Tonkaboni, Arghavan; Aledavood, Seyed Amir; Najafi, Mohsen Fathi; Delavarian, Zahra; Shakeri, Mohammad Taghi; Mohtashami, Azade
- Abstract
Objectives: Mucositis is an acute side-effect of radiotherapy, causing ulcers of the oral mucosa, pain and discomfort in patients. Propolis is a resinous substance and a rich natural resource of flavonoids, made by bees. It possesses anti-ulcer, anti-bacterial, anti-fungal, anti-oxidant and tissue-repairing properties. Use of this odorless, cost-effective substance without any unpleasant flavor, could be useful in the treatment of patients undergoing radiotherapy. Materials and Methods: This double-blinded clinical trial was conducted at the Cancer Center of Omid Hospital, affiliated to Mashhad University of Medical Sciences. Overall, 20 patients undergoing radiotherapy were randomly selected. The subjects used a mouthwash containing propolis extracts on a daily basis. Afterwards, propolis extracts were swallowed three times a day from a week before to the end of radiation therapy. In the control group, 20 patients received placebo mouthwash. The index by the National Cancer Institute was used regarding the most common complications of oral mucositis. To assess xerostomia, five standard questions, used in previous studies, were asked from the participants. For data analysis, t-test, Mann-Whitney and Friedman's Chi-square were performed. Results: The Mucositis severity was lower in the propolis group, compared to the control group. However, xerostomia was not significantly different between the two groups (p<0.1). Conclusion: This pilot study showed that mouth rinse with propolis is useful for the prevention and treatment of radiation-induced mucositis.
- Subjects
PROPOLIS; MUCOSITIS; RADIOTHERAPY complications
- Publication
Avicenna Journal of Phytomedicine, 2015, Vol 5, p145
- ISSN
2228-7930
- Publication type
Article