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- Title
Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis.
- Authors
Li, Teng; Zhang, Shujuan; Yao, Shuaibing; Li, Xuebing; Jia, Qianru; Yuan, Jingya; Zhang, Wenhua; Wang, Xuemin; Zhang, Qun
- Abstract
The dynamic changes in membrane phospholipids affect membrane biophysical properties and cell signaling, thereby influencing numerous biological processes. Nonspecific phospholipase C (NPC) enzymes hydrolyze common phospholipids to release diacylglycerol (DAG), which is converted to phosphatidic acid (PA) and other lipids. In this study, 2 Arabidopsis (Arabidopsis thaliana) tandemly arrayed genes, NPC3 and NPC4, were identified as critical factors modulating auxin-controlled plant growth and tropic responses. Moreover, NPC3 and NPC4 were shown to interact with the auxin efflux transporter PIN-FORMED2 (PIN2). The loss of NPC3 and NPC4 enhanced the endocytosis and vacuolar degradation of PIN2, which disrupted auxin gradients and slowed gravitropic and halotropic responses. Furthermore, auxin-triggered activation of NPC3 and NPC4 is required for the asymmetric PA distribution that controls PIN2 trafficking dynamics and auxin-dependent tropic responses. Collectively, our study reveals an NPC-derived PA signaling pathway in Arabidopsis auxin fluxes that is essential for fine-tuning the balance between root growth and environmental responses. Nonspecific phospholipases NPC3 and NPC4 interact with the transporter PIN-FORMED2 and regulate auxin transport and signaling.
- Subjects
TROPISMS; PHOSPHOLIPASES; PHOSPHOLIPASE C; ARABIDOPSIS; TROPICAL plants
- Publication
Plant Cell, 2024, Vol 36, Issue 6, p2310
- ISSN
1040-4651
- Publication type
Article
- DOI
10.1093/plcell/koae071