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- Title
Chemokine receptor 4 expression is correlated with the occurrence and prognosis of gastric cancer.
- Authors
Li, Yang; Wang, Hong‐Chang; Wang, Jin‐Shen; Sun, Bo; Li, Le‐Ping
- Abstract
Gastric cancer (GC) is a common tumor with a low 5‐year survival rate. The chemokine receptor 4 (CXCR4) protein contributes to the progression and prognosis of GC, but the relationship between CXCR4 and immune infiltration, somatic copy number alteration (SCNA), tumor purity, tumor mutation burden (TMB), cytolytic activity (CYT), and drug sensitivity in GC is poorly understood. This study aimed to systematically explore the role of CXCR4 in GC. Microarray and RNA‐seq data were collected from the Gene Expression Omnibus and The Cancer Genome Atlas. Our analysis shows that CXCR4 is correlated with various types of immune cells. Patients with high CXCR4 expression had a higher fraction of B cells and CD8+ T cells, and a lower fraction of CD4+ T cells. In addition, high CXCR4 expression was associated with more advanced tumor stage, worse prognosis and higher stromal score, immune score, and cytolytic activity (P < 0.05). High CXCR4 expression also correlated with lower tumor purity and TMB. In summary, our analyses suggest that CXCR4 may affect the progression and prognosis of GC by influencing immune infiltration, TMB, CYT, tumor purity, and drug sensitivity.
- Subjects
CHEMOKINE receptors; STOMACH cancer; CANCER prognosis; CXCR4 receptors; TUMOR classification; T cells
- Publication
FEBS Open Bio, 2020, Vol 10, Issue 6, p1149
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1002/2211-5463.12864