Title

Exacerbation of psoriatic arthritis due to topical imiquimod therapy.

Authors

Nakamura, Kentaro; Arakawa, Yukiyasu; Masuda, Koji; Arita, Takahiro; Katoh, Norito; Asai, Jun

Abstract

The T cells within psoriatic plaques exhibit increased responses to IFN- .[7] Furthermore, Tc17 cells that displayed a strong Trm cell signature and secreted proinflammatory cytokines were found in the synovial fluid of PsA patients.[8] Together with the patient's high-risk HLA profile, CD8 Trm cells may have aggravated her symptoms. Imiquimod has been shown to induce psoriasiform dermatitis in a murine model.[1] However, clinical cases of imiquimod-induced psoriasis are relatively rare.[[1]] We report a rare case of psoriatic arthritis (PsA) that was treated with apremilast and exacerbated by topical imiquimod. In week 10, the perianal condyloma acuminatum had resolved, but the patient complained of the exacerbation of her psoriasis plaques and distal interphalangeal (DIP) joint pain and mild swelling (Fig.

Subjects

IMIQUIMOD; PSORIATIC arthritis; DISEASE exacerbation; JOINT pain

Publication

International Journal of Dermatology, 2023, Vol 62, Issue 3, pe156

ISSN

0011-9059

Publication type

Academic Journal

DOI

10.1111/ijd.16360