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- Title
Protective effect of erdosteine on vancomycin-induced pancreatic damage in rats.
- Authors
Koyu, Ahmet; Gökalp, O.; Öktem, F.; Dönmez, S.; Doğan, M.; Karahan, N.; Gümral, N.; Yilmaz, N.
- Abstract
The aim of this study was to examine vancomycin (VCM)-induced pancreatic damage and to investigate the role of erdosteine, an expectorant and an antioxidant agent, on VCM-induced pancreas impairment in rats. Rats were divided into three groups: Control, VCM and VCM plus erdosteine. VCM was administrated intraperitoneally with 200 mg kg-1 twice daily for 7 days. Erdosteine was administered orally with 10 mg kg-1 once daily for 7 days. The first dose of erdosteine administration was performed 24 hours prior to VCM injection. Blood and pancreas tissue samples were taken after the study. Serum amylase, lipase, alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) activities were determined. And also, pancreas tissue samples were investigated under light microscopy. VCM administration significantly increased serum amylase, lipase, ALP and GGT activities as compared to control rats. VCM plus erdosteine injections caused significantly decreased serum lipase, amylase and GGT activities, but there was no difference at ALP activity in serum as compared to VCM administrated group. After light microscopic examination, there was significant pancreatic damage VCM given group as compared to control. Erdosteine showed histopathological protection against VCM- induced pancreatic damage as compared to VCM administrated group. Erdosteine caused a marked reduction in the extent of pancreatic damage. It is concluded that it plays an important role in the VCM -induced pancreatic damage and reduces the pancreatic damage both at the biochemical and histological levels.
- Publication
Cell Membranes & Free Radical Research, 2008, Vol 1, Issue 1, p25
- ISSN
1308-416X
- Publication type
Article