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- Title
Identification of Cis-regulatory Elements in the Mouse Pax9/Nkx2-9 Genomic Region: Implication for Evolutionary Conserved Synteny.
- Authors
Santagati, Fabio; Abe, Kuniya; Schmidt, Volker; Schmitt-John, Thomas; Suzuki, Misao; Yamamura, Ken-ichi; Imai, Kenji
- Abstract
Analyzes the cis-regulatory elements of the Pax9 and Nkx2-9 genes by comparative sequencing in the human, mouse, and pufferfish and by transgenesis in the mouse. Identification of two regions including conserved noncoding sequences that possessed specific enhancer activities for expression of Pax9 in the medial nasal process and of Nkx2-9 in the ventral neural tube; Possible mechanism that maintains evolutionary conserved synteny.
- Subjects
GENES; HUMAN genetics; ANIMAL genetics
- Publication
Genetics, 2003, Vol 165, Issue 1, p235
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1093/genetics/165.1.235