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- Title
Intracellular magnesium of obese and type 2 diabetes mellitus children.
- Authors
Takaya, Junji; Yamato, Fumiko; Kuroyanagi, Yuichi; Higashino, Hirohiko; Kaneko, Kazunari
- Abstract
Introduction: Magnesium is a critical cofactor in numerous enzymatic reactions. Diabetic patients and obese subjects are often reported to have intracellular magnesium ([Mg]) deficiency. We studied the change of [Mg] in obese children and children with type 2 diabetes mellitus (DM2) after educational intervention or treatment. Methods: A total of 25 subjects were included: 13 with simple obesity (10 male, 3 female; mean age 16±8 years, intervention period 1.0±0.6 years), 12 with DM2 (8 male, 4 female; mean age 15±3 years, medication period 1.1±0.7 years), and 16 controls (8 male, 8 female; mean age 17±7 years). By using a fluorescent probe, mag-fura-2, we examined the basal and insulin-stimulated [Mg] of platelets in the blood. Plasma leptin, ghrelin, adiponectin, and resistin levels were determined with the use of enzyme-linked immunosorbent assay (ELISA). Results: Mean basal [Mg] was lower in the obesity (160±65 μmol/L) and DM2 groups (140±30 μmol/L) compared with the control group (330±28 μmol/L). The elevated [Mg] after insulin stimulation was also lower in these two groups (420±140 μmol/L, and 330±70 μmol/L, respectively) compared with the control group (690±270 μmol/L). In the DM2 group, the basal [Mg] was significantly increased after treatment, while in the obesity group, stimulated [Mg] was increased after intervention. Conclusion: Platelet [Mg] increased after intervention in children with obesity or DM2.
- Publication
Diabetes Therapy, 2010, Vol 1, Issue 1, p25
- ISSN
1869-6953
- Publication type
Article
- DOI
10.1007/s13300-010-0003-7