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- Title
Does the Longer Application of Anodal-transcranial Direct Current Stimulation Increase Corticomotor Excitability Further? A Pilot Study.
- Authors
Jaberzadeh, Shapour; Bastani, Andisheh; Kidgell, Dawson
- Abstract
Introduction: Anodal transcranial direct current stimulation (a-tDCS) of the primary motor cortex (M1) has been shown to be effective in increasing corticomotor excitability. Methods: We investigated whether longer applications of a-tDCS coincide with greater increases in corticomotor excitability compared to shorter application of a-tDCS. Ten right-handed healthy participants received one session of a-tDCS (1mA current) with shorter (10 min) and longer (10+10 min) stimulation durations applied to the left M1 of extensor carpi radialis muscle (ECR). Corticomotor excitability following application of a-tDCS was assessed at rest with transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEP) and compared with baseline data for each participant. Results: MEP amplitudes were increased following 10 min of a-tDCS by 67% (p = 0.001) with a further increase (32%) after the second 10 min of a-tDCS (p = 0.005). MEP amplitudes remained elevated at 15 min post stimulation compared to baseline values by 65% (p = 0.02). Discussion: The results demonstrate that longer application of a-tDCS within the recommended safety limits, increases corticomotor excitability with after effects of up to 15 minutes post stimulation.
- Subjects
TRANSCRANIAL magnetic stimulation; MOTOR cortex; BRAIN stimulation; EVOKED potentials (Electrophysiology); MUSCLES
- Publication
Basic & Clinical Neuroscience, 2012, Vol 3, Issue 4, p28
- ISSN
2008-126X
- Publication type
Article