We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma.
- Authors
Liu, Nan; Chen, Bo; Li, Luchuan; Zeng, Qingdong; Sheng, Lei; Zhang, Bin; Lv, Bin
- Abstract
Purpose: Papillary thyroid carcinoma (PTC) has a high incidence of lymph node metastasis (LNM). Our aim was to determine whether tumor location is a useful feature to predict bilateral central lymph node metastasis (CLNM) in unilateral 1– 4 cm PTC. Patients and Methods: Data on unilateral 1– 4 cm PTC patients from 2016 to 2019 were collected retrospectively. The clinical and pathological characteristics of the tumors and lymph nodes were analyzed statistically. Results: The mean patient age was 49.1± 12.3 (23– 73) years, and the majority were women (n=1334, 75.4%). A total of 1767 patients were analyzed, and 256 (14.5%) had bilateral CLNM. Tumor location was an independent risk factor in predicting bilateral CLNM (p< 0.001). The odds of bilateral CLNM were the highest in the near isthmus (OR 6.452, 95% CI: 3.658– 11.379, p< 0.001). In a multivariate regression model adjusting for other risk factors, near-isthmus tumors had the highest risk of bilateral CLNM (OR 7.319, 95% CI: 3.844– 13.933, p< 0.001), followed by lower lobe tumors (OR 2.338, 95% CI: 1.315– 4.155, p=0.004) and middle lobe tumors (OR 1.845, 95% CI: 1.035– 3.291, p=0.038), compared to upper lobe tumors. Conclusion: Tumor location is an independent risk factor in predicting the risk of bilateral CLNM. Near-isthmus tumors carry the highest risk of bilateral CLNM.
- Subjects
LYMPHATIC metastasis; PAPILLARY carcinoma; THYROID cancer; TUMORS
- Publication
Cancer Management & Research, 2021, Vol 13, p5803
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S318076