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- Title
Asymmetric Henry Reaction of Trifluoromethyl Enones with Nitromethane Using a N,N-Dibenzyl Diaminomethylenemalononitrile Organocatalyst.
- Authors
Masahiro Kawada; Ryo Tsuyusaki; Kosuke Nakashima; Misaki Yamada; Akihiro Kozakai; Yasuyuki Matsushima; Shin-ichi Hirashima; Tsuyoshi Miura
- Abstract
A novel N,N-dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promoted asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee). This study is the first to report the successful example of the asymmetric 1,2-additions of nitromethane to trifluoromethyl enones.
- Subjects
NITROALDOL reactions; NITROMETHANE; CARBONYL compounds
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 4, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202101299