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- Title
Biotransformation of a biosynthetic intermediate mimic of nonactin by Streptomyces griseus.
- Authors
Hanadatea, Tadaatsu; Takaia, Kentaro; Abe, Naoki; Yamada, Teiko; Kuwahara, Shigefumi; Kiyota, Hiromasa
- Abstract
A mimic of a plausible biosynthetic intermediate of bishomononactic acid, one of the monomers of macrotetrolide antibiotics (polynactin), was synthesized as a thiol ester. FAB-MS analysis showed that fermentation of polynactin producing Streptomyces griseus with the compound, afforded the unnatural polynactins containing bishomononactic acid(s).
- Subjects
STREPTOMYCES griseus; BIOTRANSFORMATION (Metabolism); ANTIBIOTICS; THIOLS; FOURIER transform infrared spectroscopy; NUCLEAR magnetic resonance; MONOMERS; NONACTIN
- Publication
Heterocyclic Communications, 2011, Vol 17, Issue 3/4, p93
- ISSN
0793-0283
- Publication type
Article
- DOI
10.1515/HC.2011.021