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- Title
Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea.
- Authors
Cao, Duc Danh; Trinh, Thi Thanh Van; Doan Thi Mai, Huong; Vu, Van Nam; Le, Hong Minh; Vu Thi, Quyen; Nguyen, Mai Anh; Duong, Thu Trang; Tran, Dang Thach; Chau, Van Minh; Ma, Rui; Shetye, Gauri; Cho, Sanghyun; Murphy, Brian T.; Pham, Van Cuong
- Abstract
Three new lavandulylated flavonoids, (2S,2″S)-6-lavandulyl-7,4′-dimethoxy-5,2′-dihydroxylflavanone (1), (2S,2″S)-6-lavandulyl-5,7,2′,4′-tetrahydroxylflavanone (2), and (2″S)-5′-lavandulyl-2′-methoxy-2,4,4′,6′-tetrahydroxylchalcone (3), along with seven known compounds 4–10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of 1–3 were resolved by comparison of their experimental and calculated electronic circular dichroism spectra. Compounds 1–3 exhibited remarkable antimicrobial activity. Whereas, two known compounds 4 and 5 exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv with minimum inhibitory concentration (MIC) values of 6.0 µg/mL and 11.1 µg/mL, respectively.
- Subjects
VIETNAM; STREPTOMYCES; CIRCULAR dichroism; FLAVONOIDS; NUCLEAR magnetic resonance; QUINAZOLINONES; ELECTROSPRAY ionization mass spectrometry; MYCOBACTERIUM tuberculosis
- Publication
Marine Drugs, 2019, Vol 17, Issue 9, p529
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17090529