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- Title
Association of Versican Gene Polymorphisms with Intracranial Aneurysm Susceptibility in the Eastern Chinese Population.
- Authors
Zhu, Lei; Yu, Chuanqing; Zhou, Shuping; Xue, Min; Chen, Jie; Wu, Meijun; Dong, Shuyang; Huang, Guanmin; Chang, Yueyue; Zhang, Mei
- Abstract
aimed to investigate the associations of the SNPs rs251124, rs2287926, and rs173686 with IA susceptibility in the Eastern Chinese population. Methods: A total of 162 patients with IA and 182 controls were enrolled in this study. The study was conducted between January 2017 and December 2020. SNP genotyping for rs251124, rs2287926, and rs173686 was performed using Kompetitive Allele Specific PCR (KASP) after DNA extraction. The SNP data were analysed with CFX Manager Software version 3.1 (Bio-Rad). Results: rs251124 and rs173686 were significantly associated with susceptibility to IA. The frequency of rs251124-TT in IA was higher than in controls (OR =1.26, 95% CI: 1.07– 1.49; P< 0.01), and its risk mainly came from the T allele. Furthermore, logistic regression analysis showed that the T/T genotype and T allele of rs251124 were independent risk factors for IA (OR=1.726, 95% CI: 1.136– 2.263; P=0.011). Moreover, the G/G genotype and G allele of rs173686 were associated with increased IA susceptibility (OR=2.52, 95% CI: 1.261– 5.037; P=0.009). Conclusion: The SNPs rs251124 and rs173686 were strongly associated with genetic susceptibility to IA in the Eastern Chinese population; however, no such association was found in the SNP rs2287926 of VCAN. Our findings suggest that the VCAN gene is an IA susceptible gene that should be further studied as a screening marker for IAs.
- Subjects
CHINESE people; GENETIC polymorphisms; INTRACRANIAL aneurysms; LOGISTIC regression analysis; SINGLE nucleotide polymorphisms
- Publication
Neuropsychiatric Disease & Treatment, 2021, Vol 17, p3531
- ISSN
1176-6328
- Publication type
Article
- DOI
10.2147/NDT.S338311