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- Title
An analysis of risk factors for spontaneously occurring type 2 diabetes mellitus in rhesus macaques (Macaca mulatta).
- Authors
Capitanio, John P.; Del Rosso, Laura A.; Yee, JoAnn; Lemoy, Marie‐Josee Marie‐France
- Abstract
Background: Type 2 Diabetes Mellitus (T2D) is a chronic disease with a high prevalence worldwide. Human literature suggests factors beyond well‐known risk factors (e.g., age, body mass index) for T2D: cytomegalovirus serostatus, season of birth, maternal age, birth weight, and depression. Nothing is known, however, about whether these variables are influential in primate models of T2D. Methods: Using a retrospective methodology, we identified 22 cases of spontaneously occurring T2D among rhesus monkeys at our facility. A control sample of n = 1199 was identified. Results: Animals born to mothers that were ≤5.5 years of age, and animals that showed heightened Activity and Emotionality in response to brief separation in infancy, had a greater risk for development of T2D in adulthood. Conclusions: Knowledge of additional risk factors for T2D could help colony managers better identify at‐risk animals and enable diabetes researchers to select animals that might be more responsive to their manipulations.
- Subjects
TYPE 2 diabetes; MACAQUES; RHESUS monkeys; FACTOR analysis; MATERNAL age; RISK assessment
- Publication
Journal of Medical Primatology, 2024, Vol 53, Issue 2, p1
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/jmp.12695