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- Title
Effects of Pinitol on Glycemic Control, Insulin Resistance and Adipocytokine Levels in Patients with Type 2 Diabetes Mellitus.
- Authors
Kim, Hyun Jin; Park, Kang Seo; Lee, Seong Kyu; Min, Kyung Wan; Han, Kyung Ah; Kim, Young Kun; Ku, Bon Jeong
- Abstract
Background: Pinitol is thought to mediate insulin action and improve insulin resistance. We evaluated the effects of pinitol on glycemic control, insulin resistance and adipocytokine levels in type 2 diabetic patients. Material and Method: A total of 66 patients with type 2 diabetes who had been taking oral hypoglycemic agents for at least 3 months were enrolled and randomized to receive pinitol (n = 33) or matching placebo (n = 33). All subjects took 1,200 mg pinitol or placebo and maintained their current oral hypoglycemic agents throughout the study. Results: Mean HbA1c, fasting plasma glucose, and HOMA-IR were significantly lowered more in patients taking pinitol than in those given a placebo. Patients who had an HbA1c over 8.0% showed a greater reduction (p < 0.01) than those who had an HbA1c below 8.0% (p =0.16). In addition, in the group of patients with a HOMA-IR over 2.5, there was a significant decrease in HbA1c compared to that in the group of patients with a HOMA-IR below 2.5. There were no differences in the changes in adiponectin, FFA and CRP between the two groups. Conclusions: Pinitol can mediate insulin action to improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus, especially in patients with insulin resistance. Copyright © 2011 S. Karger AG, Basel
- Subjects
CYTOKINES; DIABETES; GLYCOSYLATED hemoglobin; INOSITOL; INSULIN resistance; METABOLIC regulation; TYPE 2 diabetes
- Publication
Annals of Nutrition & Metabolism, 2012, Vol 60, Issue 1, p1
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000334834