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- Title
Syntheses and Antibacterial Studies of Some 2-[5-(Aryl)-[l,3,4]oxadiazole-2-ylsulfanyl] alkanoic Acids.
- Authors
Jain, N.; Pathak, D. P.; Mishra, P.; Jain, S.
- Abstract
Some new 2-[5-(aryl)-[1,3,4]oxadiazole-2-ylsulfanyl]alkanoic acids were synthesized and studied for their antibacterial activity. These compounds were prepared from aromatic carboxylic acid hydrazides. Aromatic carboxylic acid hydrazides 1 on refluxing with carbon disulfide and methanolic potassium hydroxide and then on subsequent acidification with hydrochloric acid furnish 5-aryl-1,3,4-oxadiazole-2-thiones 2. 2-Chloro alkanoic acids react with 2 in alkaline media and on acidification yield the title compounds 3. These compounds were characterised by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined.
- Subjects
ALKANOIC acids; CARBOXYLIC acids; ANTIBACTERIAL agents; AROMATIC compounds; HYDROCHLORIC acid; ESCHERICHIA coli
- Publication
Journal of the Iranian Chemical Society, 2009, Vol 6, Issue 1, p77
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/BF03246504