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- Title
Curcumin modulates cellular AP-1, NF-κB, and HPV16 E6 proteins in oral cancer.
- Authors
Mishra, Alok; Kumar, Rakesh; Tyagi, Abhishek; Kohaar, Indu; Hedau, Suresh; Bharti, Alok C.; Sarker, Subhodeep; Dey, Dipankar; Saluja, Daman; Das, Bhudev
- Abstract
In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-κB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.
- Subjects
ANTIOXIDANTS; CURCUMIN; CELL lines; CANCER cells; ONCOLOGY research
- Publication
Ecancermedicalscience, 2015, Vol 9, Issue 519-548, p1
- ISSN
1754-6605
- Publication type
Article
- DOI
10.3332/ecancer.2015.525