We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice.
- Authors
Henry, Brian D; Neill, Daniel R; Becker, Katrin Anne; Gore, Suzanna; Bricio-Moreno, Laura; Ziobro, Regan; Edwards, Michael J; Mühlemann, Kathrin; Steinmann, Jörg; Kleuser, Burkhard; Japtok, Lukasz; Luginbühl, Miriam; Wolfmeier, Heidi; Scherag, André; Gulbins, Erich; Kadioglu, Aras; Draeger, Annette; Babiychuk, Eduard B
- Abstract
Gram-positive bacterial pathogens that secrete cytotoxic pore-forming toxins, such as Staphylococcus aureus and Streptococcus pneumoniae, cause a substantial burden of disease. Inspired by the principles that govern natural toxin-host interactions, we have engineered artificial liposomes that are tailored to effectively compete with host cells for toxin binding. Liposome-bound toxins are unable to lyse mammalian cells in vitro. We use these artificial liposomes as decoy targets to sequester bacterial toxins that are produced during active infection in vivo. Administration of artificial liposomes within 10 h after infection rescues mice from septicemia caused by S. aureus and S. pneumoniae, whereas untreated mice die within 24-33 h. Furthermore, liposomes protect mice against invasive pneumococcal pneumonia. Composed exclusively of naturally occurring lipids, tailored liposomes are not bactericidal and could be used therapeutically either alone or in conjunction with antibiotics to combat bacterial infections and to minimize toxin-induced tissue damage that occurs during bacterial clearance.
- Subjects
INFECTION treatment; POLYMERSOMES; LIPOSOMES; EXOTOXIN; SEPTICEMIA treatment; STAPHYLOCOCCUS aureus; STREPTOCOCCUS pneumoniae
- Publication
Nature Biotechnology, 2015, Vol 33, Issue 1, p81
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.3037