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- Title
SNP imputation in association studies.
- Authors
Halperin, Eran; Stephan, Dietrich A
- Abstract
This article discusses research on new techniques for assessing the amount of data that derives from the genotyping of hundreds of thousands of single-nucleotide polymorphisms (SNPs) within whole-genome association studies. While it is understood how to correlate tagSNPs and haplotypes to neighboring associations, consolidating distinct data sets when subsets of the same population are genotyped with varying technologies has presented a problem. It has been discovered that imputation methods can address this problem by using the disequilibrium structure in a region to infer the alleles of SNPs not specifically genotyped in a study. Successful applications of this have identified associations for Crohn's disease following meta-analysis of data sets.
- Subjects
GENETIC polymorphism research; NUCLEOTIDES; GENOMICS; HAPLOIDY; DATA analysis; STATISTICAL matching; CROHN'S disease; META-analysis
- Publication
Nature Biotechnology, 2009, Vol 27, Issue 4, p349
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0409-349