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- Title
Telomere-dependent senescence.
- Authors
Kipling, David; Wynford-Thomas, David; Jones, Chris J.; Akbar, Arne; Aspinall, Richard; Bacchetti, Silvia; Blasco, Maria A.; Broccoli, Dominique; DePinho, Ron A.; Edwards, Dylan R.; Effros, Rita B.; Harley, Calvin B.; Lansdorp, Peter M.; Linskens, Maarten H.K.; Prowse, Karen R.; Newbold, Robert F.; Olovnikov, Alexey M.; Parkinson, E. Kenneth; Pawelec, Graham
- Abstract
Discusses the impact of telomerase erosion on the division capacity of fibroblasts. Challenges facing researchers to explore the details of telomerase-dependent senescence; Relationship between fibroblast replicative potential and donor age; Importance of functional telomeres for long-term chromosome viability in eukaryotes.
- Subjects
TELOMERASE; FIBROBLASTS; AGING
- Publication
Nature Biotechnology, 1999, Vol 17, Issue 4, p313
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/7827