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- Title
Correlation between Osteoprotegerin Levels and Antiphospholipid Syndrome Parameters.
- Authors
Caraiola, Simona; Dima, Alina; Jurcut, Ciprian; Jurcut, Ruxandra; Baicus, Cristian; Baicus, Anda
- Abstract
Objective To identify the osteoprotegerin (OPG) correlates with antiphospholipid syndrome (APS) parameters. Methods Our cohort included 40 patients with primary APS disease associated with systemic lupus erythematosus (SLE) (mean age, 43.7 years; 87% female). Data on cardiovascular risk factors and specific clinical events in APS were collected. Then we tested OPG and 10 criteria and noncriteria antiphospholipid antibodies (aPLs) on preserved specimens in all cases. Results A total of 26 patients (65%) had high serum OPG levels. Patients with high OPG were mostly overweight. In patients with SLE, the OPG levels were associated with anti–double-stranded DNA (anti-dsDNA) and anti-Sm titers. However, we did not find significant correlations of the OPG with any of the 10 aPLs tested. Also, we found no relationship regarding venous APS events. Conclusion In APS, high OPG levels are not linked to serum aPL expression.
- Subjects
AGE distribution; ANTHROPOMETRY; ANTIPHOSPHOLIPID syndrome; CARDIOVASCULAR diseases risk factors; CELL receptors; CONFIDENCE intervals; GLYCOPROTEINS; MULTIVARIATE analysis; SEX distribution; SYSTEMIC lupus erythematosus; BODY mass index; CROSS-sectional method; WAIST-hip ratio; DISEASE duration; DATA analysis software; MANN Whitney U Test; BLOOD; DISEASE complications
- Publication
Laboratory Medicine, 2020, Vol 51, Issue 2, p193
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmz051