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- Title
Chronic endometritis diagnosed using a cut-off of ≥5 CD138 plasma cells significantly affects the reproductive outcomes of frozen embryo transfer: a case-control study.
- Authors
Bulut, Hasan; Yeğinaltay, Tamer; Tunç, Mustafa; Berkkanoğlu, Murat; Töre, Hande; Coetzee, Kevin; Özgür, Kemal
- Abstract
Objective: To investigate the clinical significance of a diagnosis of chronic endometritis (CE) made using a diagnostic cut-off of ≥1 or ≥5 CD138 plasma cells per high power field (HPF) in asymptomatic patients undergoing in vitro fertilization (IVF) with frozen embryo transfer (FET). Material and Methods: In this retrospective case-control study, 1,865 patients underwent freeze-all-IVF treatment between January and December 2019, with 419 undergoing endometrial biopsies at oocyte retrieval. Of the 419 biopsy-patients, 301 have since undergone first FET. The processed endometrial biopsies of the 301 patients underwent immunohistochemical (IHC) examination with anti-CD138 to count CD138+ plasma cells per HPF. CE diagnosis was defined as 0 CD138 plasma cells (control-group), ≥1 CD138 plasma cells (CEcontrol-group) or ≥5 CD138 plasma cells (CEdisease-group) per HPF. Results: Twenty-six (8.6%) patients were retrospectively diagnosed having >1 CD138 plasma cells, and five patients (1.7%) having ≥5 CD138 plasma cells (CEdisease-group) per HPF. The live birth and pregnancy loss rates of the three groups were 52.7% and 27.9%, 53.8% and 26.3% and 20.0% and 66.7%, respectively. The antral follicle count (AFC) of the three groups were 15.0 (9.0-22.0), 10.5 (7.75-15.25), and 6.0 (5.0-14.0), respectively. Conclusion: Asymptomatic patients diagnosed with CE with ≥5 CD138 plasma cells per HPF, had the lowest live birth and highest pregnancy loss rates, with these patients also having significantly reduced AFC.
- Subjects
DIAGNOSIS of endometrial diseases; CHRONIC disease diagnosis; BIOPSY; OOCYTE retrieval; MICROSCOPY; IMMUNOHISTOCHEMISTRY; CASE-control method; RETROSPECTIVE studies; MANN Whitney U Test; EMBRYO transfer; PREGNANCY outcomes; ANTIBIOTIC prophylaxis; GLYCOPROTEINS; CHI-squared test; DESCRIPTIVE statistics; FERTILIZATION in vitro; DATA analysis software; ENDOMETRIUM
- Publication
Journal of the Turkish-German Gynecological Association, 2023, Vol 24, Issue 3, p165
- ISSN
1309-0399
- Publication type
Article
- DOI
10.4274/jtgga.galenos.2023.2022-9-20