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- Title
A facile preparation of p H-temperature dual stimuli-responsive supramolecular hydrogel and its controllable drug release.
- Authors
Zhou, Mi; Liu, Kaiyue; Qian, Xin
- Abstract
ABSTRACT A series of pH-temperature dual stimuli-responsive random copolymers poly[ N,N-dimethylaminoethyl methacrylate- co-poly(poly(ethylene glycol) methyl ether methacrylate][poly(DMAEMA- co-MPEGMA)] were synthesized by free radical polymerization. The supramolecular hydrogel was formed by pseudopolyrotaxane, which was prepared with the host-guest interactions between α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG) side chains. Fourier transform infrared (FT-IR), nuclear magnetic resonance (1H NMR), and X-ray diffraction (XRD) confirmed the structures of the hydrogels. The pH-temperature dual stimuli responsive properties of the hydrogels were characterized by rheometer. Finally, the controllable drug release behavior of the hydrogel, which was used 5-fluorouracil (5-Fu) as the model drug, was investigated at different temperatures and different pH values. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43279.
- Subjects
DRUG delivery systems; HYDROGELS; MOLECULAR self-assembly; POLYMER research; SUPRAMOLECULAR polymers synthesis
- Publication
Journal of Applied Polymer Science, 2016, Vol 133, Issue 15, pn/a
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.43279