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- Title
No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine.
- Authors
Cernuda‐Morollón, Eva; Riesco, Nuria; Martínez‐Camblor, Pablo; Serrano‐Pertierra, Esther; García‐Cabo, Carmen; Pascual, Julio
- Abstract
Objective To determine total pituitary adenylate cyclase activating polypeptide (PACAP) in peripheral blood as a potential marker of the activation of the parasympathetic arm of the trigemino-vascular system in chronic migraine (CM) in a case-control study. Methods Women older than 17 and diagnosed as CM were recruited. Healthy women with no headache history and women with episodic migraine (EM) served as control groups. Total PACAP and vasoactive intestinal peptide (VIP) levels were determined in blood samples obtained from the right antecubital vein by ELISA outside a migraine attack and having taken no symptomatic medication the day before. Results We assessed serum samples from 86 women with CM, 32 healthy women, and 35 women with EM. There were no differences in PACAP levels in CM patients (109.8 ± 43.8, 97.4 [32.5-253.1] pg/mL), controls (108.7 ± 43.0, 98.7 [50.7-197.3] pg/mL), or EM patients (98.8 ± 34.3, 94.2 [52.0-190.7] pg/mL). VIP levels were significantly increased ( P = .027) in CM as compared to control healthy women (136.0 ± 111.5 pg/mL; 103.1 [20.5-534.0] pg/mL vs 88.6 ± 61.0 pg/mL; 66.0 [21.1-256.1]) and EM patients (103.0 ± 56.7 pg/mL; 103.5 [15.2-263.0] pg/mL). In the range of this study variables such as age, CM duration, the presence of aura, analgesic overuse, depression, fibromyalgia, vascular risk factors, history of triptan consumption or kind of preventative treatment did not significantly influence PACAP or VIP levels. Conclusion In contrast to VIP, interictal PACAP level measured in peripheral blood does not seem to be a biomarker reflecting parasympathetic activation in CM.
- Subjects
ANALYSIS of variance; BIOMARKERS; CHI-squared test; CHRONIC pain; MIGRAINE; NEUROPEPTIDES; PARASYMPATHETIC nervous system; PROBABILITY theory; RESEARCH funding; STATISTICS; DATA analysis; DATA analysis software; MANN Whitney U Test; KRUSKAL-Wallis Test
- Publication
Headache: The Journal of Head & Face Pain, 2016, Vol 56, Issue 9, p1448
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/head.12949