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- Title
Serotonin Depletion Leads to Cortical Hyperexcitability and Trigeminal Nociceptive Facilitation via the Nitric Oxide Pathway.
- Authors
le Grand, Supang Maneesri; Supornsilpchai, Weera; Saengjaroentham, Chonlawan; Srikiatkhachorn, Anan
- Abstract
The article examines how nitric oxide (NO) acts in the development of cortical hyperexcitability and trigeminal nociceptive facilitation induced by serotonin (5-HT) depletion. Inhibition of NO production can offset both the cortical hyperexcitability and facilitation of trigeminal nociception that form in the diminished 5-HT state. Hence, NO is likely involved in the increase in both cortical spreading depression (CSD) events and CSD-evoked trigeminal nociception under depleted 5-HT conditions.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; COMPUTER software; HEADACHE; NITRIC oxide; PROBABILITY theory; RATS; RESEARCH funding; SEROTONIN; STATISTICS; U-statistics; DATA analysis
- Publication
Headache: The Journal of Head & Face Pain, 2011, Vol 51, Issue 7, p1152
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2011.01931.x