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- Title
Plasma 5-Hydroxytryptamine (5-HT) in Migraine During an Attack-Free Period.
- Authors
Nagata, Eiichiro; Shibata, Mamoru; Hamada, Junichi; Shimizu, Toshihiko; Katoh, Yuki; Gotoh, Kyoko; Suzuki, Norihiro
- Abstract
Objective.—We measured the plasma 5-HT, 5-hydroxytryptophan (5-HTP), and tryptophan levels in controls, migraine patients with aura (MWA), and migraine patients without aura (MWoA) during an attack-free period. Background.—Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of migraine. The precise relationship between 5-HT and migraine, however, remains unclear. Methods.—Blood samples in controls, MWA, and MWoA patients during an attack-free period were collected from brachial arteries and analyzed using HPLC. Results.—The plasma tryptophan and 5-HTP levels were not significantly different between the controls and migraine patients (either MWA or MWoA). However, the plasma 5-HT level in the MWA patients was significantly lower than that in the controls and MWoA patients. Conclusions.—The present data suggest that reduced levels of 5-HT in MWA may result from either a dysfunction in the enzymes involved in serotonin biosynthesis or a dysfunction in 5-HT release or uptake from platelets and lymphocytes. These findings indicate the existence of a serotonin metabolism dysfunction in MWA patients that may differ from the state of serotonin metabolism in MWoA patients.
- Subjects
SEROTONIN; MIGRAINE; BRACHIAL artery; PATHOLOGICAL physiology; METABOLISM
- Publication
Headache: The Journal of Head & Face Pain, 2006, Vol 46, Issue 4, p592
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2006.00408.x