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- Title
A polymorphism in the interleukin-1[alpha] gene influences the clinical features of migraine.
- Authors
Rainero I; Pinessi L; Salani G; Valfrè W; Rivoiro C; Savi L; Gentile S; Giudice RL; Grimaldi LM
- Abstract
Objective.-To evaluate whether a particular genotype of the interleukin-1[alpha] (IL1A ) gene affects the clinical features of migraine. Background.-Proinflammatory mediators have been reported to play a role in the pathophysiology of migraine. Recent studies suggest that polymorphisms in the interleukin-1 genes influence the age at onset and subsequent course of several chronic inflammatory diseases. Methods.-In a group of 269 patients with migraine, we tested the association of the -889 C/T biallelic polymorphism of the IL1A gene with several clinical features of the disease. Results.-Patients with migraine carrying the T/T genotype show an age at onset of the disease that is significantly (P < .01) lower than IL1A C/C or C/T carriers. In addition, the same genotype was significantly (P < .05) more frequent in patients with migraine with aura than in patients with migraine without aura. Conclusions.-The results of our study suggest a role for the IL1A gene in modifying the clinical features of migraine.
- Publication
Headache: The Journal of Head & Face Pain, 2002, Vol 42, Issue 5, p337
- ISSN
0017-8748
- Publication type
Journal Article
- DOI
10.1046/j.1526-4610.2002.02103.x