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- Title
T Cells from the Peripheral Blood of Coeliac Disease Patients Recognize Gluten Antigens when Presented by HLA-DR, -DQ, or -DP Molecules.
- Authors
Gjertsen, H. A.; Sollid, L. M.; Ek, J.; Thorsby, E.; Lundin, K. E. A.
- Abstract
Coeliac disease (CD) is a T-cell mediated immunological disease of the small intestine which is precipitated in susceptible individuals by ingestion of gluten. We recently reported that gliadin-specific T cells can be found in the small intestinal mucosa of CD patients, and that a preponderance of these T cells was restricted by the CD-associated DQ(α1*0501,β1*0201) heterodimer. Here we report studies on whether the same is found for gliadin specific T cells in the peripheral blood of CD patients. T-cell responses towards gluten antigens <em>in vitro</em> were found for both most CD patients and healthy controls. Gluten-specific T-cell clones (TCC) were established from four CD patients. Although a large proportion of these TCC were restricted by DQ molecules, including the CD-associated DQ(α1*0501,β1*0201) heterodimer, several were restricted instead by DR or DP molecules. Thus, gluten-derived peptides can be presented to T cells by several different HLA class-II molecules, and the preferential DQ(α1*0501,β1*0201) restriction of gluten-specific T cells in the small intestinal mucosa of CD patients is less pronounced than for similar T cells in the peripheral blood.
- Subjects
CELIAC disease; T cells; SMALL intestine; GLUTEN; BLOOD
- Publication
Scandinavian Journal of Immunology, 1994, Vol 39, Issue 6, p567
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1994.tb03414.x