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- Title
Has Immunoglobulin Come to a Sticky End?
- Authors
Langman, R. E.; Cohn, M.
- Abstract
The article reports that the immunoglobulin molecule (Ig) is unique in that it has been selected during evolution to carry out two very different functions upon interaction with antigen. First, there is its regulatory role, in which the Ig functions as the B-cell antigen receptor that communicates a signal to the cell. Second there is its defensive role, in which the Ig is secreted into solution, where its interaction with antigen activates a destructive ridding effector activity. Detailed argument at the conceptual and experimental level is presented to show that these two functions must be mediated by two different mechanisms.
- Subjects
IMMUNOGLOBULINS; GLOBULINS; PLASMA cells; BLOOD proteins; ANTIGENS; B cells
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 2, p99
- ISSN
0300-9475
- Publication type
Editorial
- DOI
10.1111/j.1365-3083.1991.tb03739.x