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- Title
Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow.
- Authors
Niu, Hongmei; Wei, Zhenzhen; Zhang, Yanling; He, Jian; Jia, Danyan
- Abstract
The underlying mechanisms behind the effect of atorvastatin on patients with coronary slow flow (CSF) remain largely unknown. To investigate the possible underlying molecular mechanisms 108 patients were divided into atorvastatin group and control group. Coronary flow was quantified according to corrected TIMI frame count (CTFC). Serum high sensitivity C-reactive protein (hs-CRP), lipids, ET-1, interleukin (IL)-6, NO, circulating endothelial progenitor cell (cEPC) count, adhesion, migration and proliferation were measured in pretreatment and post-treatment. After respective treatment, the atorvastatin group had significantly decreased levels of TC, TG, LDL-C, hs-CRP, ET-1 and IL-6 and increased NO compared to the control group. The atorvastatin group had a more significant improvement of CTFC, effective rate, cEPC number, EPC adhesion, migration and proliferation compared to the control group. In conclusion, atorvastatin can be used in treatment of CSF by suppressing inflammation and improving endothelial function.
- Subjects
ATORVASTATIN; ENDOTHELIAL cells; CORONARY circulation; PROGENITOR cells; INTERLEUKIN-6; PHYSIOLOGY
- Publication
Experimental & Therapeutic Medicine, 2018, Vol 15, Issue 1, p904
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2017.5484