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- Title
High-throughput sequencing of autism spectrum disorders comes of age.
- Authors
WANG, MINGBANG; FAN, XIAOMEI; WANG, TAO; WU, JINYU
- Abstract
Autism spectrum disorders (ASDs) are lifelong neurodevelopmental disabilities that affect 1 in 88 children in the USA. Despite the high heritability, the genetic basis for a majority of the ASDs remains elusive. The considerable clinical and genetic heterogeneity pose a significant challenge technically. State-of-the-art high-throughput sequencing (HTS), which makes the analyses of any specific single/multiple genes or whole exomes feasible, has shown a promising perspective in disease gene discovery. To date, numerous genetic studies using HTS have been reported and many rare inherited or de novo mutations have been identified. This review will focus on the progress and prospective of genome studies of ASDs using HTS.
- Subjects
UNITED States; AUTISM spectrum disorders; NUCLEOTIDE sequence; GENETIC mutation; HUMAN genome; DEVELOPMENTAL disabilities
- Publication
Genetics Research, 2013, Vol 95, Issue 4, p121
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672313000153