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- Title
The importance of glycerin-containing negative control tests in allergy research studies that use intradermal skin tests
- Authors
Hurst, David S.; Gordon, Bruce R.; Krouse, John H.
- Abstract
Objective: We sought to assess skin whealing with glycerin-containing control injections for intradermal skin tests. Design: Observational. Methods: Wheal sizes were measured at 0, 10, and 15 minutes after intradermal injection of 0.01 and 0.02 mL of phenolated normal saline and 0.5% and 5% concentrations of glycerin in the same quantity of phenolated saline. Results: Intradermal injection of 0.01 mL of phenolated saline produced an average 4.9-mm wheal, which expanded to 5.2 mm at 10 minutes and to 6.0 mm at 15 minutes. Intradermal injection of 0.02 mL of phenolated saline produced a 6.4-mm wheal, which expanded to 7.0 mm at 10 minutes and 8.0 mm at 15 minutes. The addition of glycerin produced proportionally larger wheals. Conclusions: Because glycerin increases whealing beyond that with phenolated saline, skin tests containing glycerin must be compared with glycerin-containing negative controls. Intradermal skin tests that fail to compare findings in this manner contain an inherent methodologic flaw and are uninterpretable. (Otolaryngology Head Neck Surg 2002;127:177-81.)
- Subjects
SKIN tests; GLYCERIN; INTRADERMAL injections; THERAPEUTICS
- Publication
Otolaryngology-Head & Neck Surgery, 2002, Vol 127, Issue 3, p177
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1067/mhn.2002.127890